A symbol of medieval Guardiagrele, it is the town’s most significant and complex monument. Rising in the early 13th century, it has undergone continuous transformations, making it an extremely architecturally complex building. The Maiella stone facade is dominated by the massive bulk of the bell tower, at the base of which opens one of the most beautiful portals of Abruzzo Gothic, dating from around 1430. The two side porticos both date from the 14th century, and under the columned one on the right side are the large St. Christopher, frescoed by Andrea Delitio in 1473, and an elegant Renaissance portal; under the left one is the fine 15th-century fresco of the Madonna del Riparo (or Madonna del Latte). The wide Baroque nave is the result of an early 18th-century elevation and preserves altars and canvases of the period. The ground floor houses the Cathedral Museum, with the 1431 cross by Nicola da Guardiagrele and other valuable works of art. At the back is the Baroque crypt dedicated to San Rocco.